Table 1.
Conformational deviations between the two different states of GTPases in terms of angles made by the resultant phase vectors corresponding to P loop, SWI, and SWII regions with y axis
| Structures used for the comparison | P loop | SWI | SWII |
|---|---|---|---|
| Cdc42 wt (GTP) – Cdc42 wt (GDP) | 10.16 | 7.49∗ | 6.76∗ |
| KRaswt (GTP) – KRaswt (GDP) | 27.69 | 7.43∗ | 6.05∗ |
| Rab11 wt (GTP) – Rab11 wt (GDP) | 1.45 | 8.54∗ | 6.37∗ |
| Arf6wt (GTP) – Arf6wt (GDP) | 17.13 | 7.41+ | 9.79+ |
| Cdc42 wt (GTP) – Cdc42G12V (GDP) | 13.34 | 14.23¶ | 6.26¶ |
| KRaswt (GTP) – KRasG12V (GDP) | 12.70 | 8.96¶ | 10.39¶ |
| Cdc42morphed (GTP) – Cdc42 wt (GDP) | 13.14 | 21.29§ | 11.19§ |
| Cdc42 wt (GDP) – Cdc42G12V (GDP) | 7.68 | 22.79 | 11.53 |
| KRaswt (GDP) – KRasG12V (GDP) | 0.80 | 1.73 | 3.45 |
The GTPases that show similar trend in their SWI and SWII phase angles are highlighted with ∗, the divergent Arf6 is highlighted with +. G12V mutants are highlighted with ¶ and the phase angles for the morphed Cdc42 (GTP) is highlighted with §.