TABLE 1.
Source and descriptive Information of GWAS data used in mendelian randomization.
| Phenotypes | Ancestry | Sample size | Method of measurement | Adjustments | PMID |
|---|---|---|---|---|---|
| Plasma proteins | European | 35,559 | SomaScan | Age, sex and sample age | 34857953 |
| eBMD (Primary analysis) | European | 426,824 | Ultrasound | Age, sex, genotyping array, assessment center, and ancestry informative principal components 1 to 20 | 30598549 |
| TBBMD (Secondary analysis) | European | 56,284 | DXA | Age, sex, weight, height, genomic principal components, study-specific covariates | 29304378 |
| LSBMD (Secondary analysis) | Predominantly European (∼70%) | 44,731 | DXA | Sex, age, age2, weight | 26367794 |
| FNBMD (Secondary analysis) | Predominantly European (∼70%) | 49,988 | DXA | Sex, age, age2, weight | 26367794 |
| Fracture (Secondary analysis) | European | 426,795 (53,184 cases) | Hospital-based and self-reported fracture history | Age, sex, genotyping array, assessment center, and ancestry informative principal components 1 to 20 | 30598549 |