Table 2.

Regions with functional changes (ALFF, ReHo, and FC) between MCI and HC.

Cluster	Volume(mm3)	MNI			Anatomical regions	Maximum ALE value	Side	BA
		X	Y	Z
ALFF/fALFF
MCI > HC
1	18,960	−54	−54	28	Superior temporal gyrus	0.00817	Left	39
1	18,960	−50	−63	29	Middle temporal gyrus	0.007665	Left	39
MCI<HC
1	19,440	−42	−74	36	Middle temporal gyrus	0.010179	Left	39
1	19,440	−50	−64	30	Middle temporal gyrus	0.007669	Left	39
2	10,464	36	39	21	Middle frontal gyrus	0.007415	Right	9
3	10,016	60	−42	0	Middle temporal gyrus	0.00817	Right	22
4	9,488	0	26	60	Superior frontal gyrus	0.009786	Left	6
5	8,752	42	−45	57	Angular gyrus	0.007665	Left	40
6	8,448	−9	21	24	Cingulate gyrus	0.009733	Left	24
7	8,360	24	12	42	Cingulate gyrus	0.010494	Right	24
ReHo
MCI > HC
1	16,064	51	−27	9	Middle temporal gyrus	0.006546	Right	41
2	16,008	−54	−9	0	Superior temporal gyrus	0.006939	Left	22
3	12,080	36	−33	−24	Parahippocampal gyrus	0.008758	Right	36
4	10,008	−62	−44	23	Inferior parietal lobule	0.009139	Left	40
MCI<HC
1	12,688	−50	18	28	Middle frontal gyrus	0.009466	Left	9
1	12,688	−40	4	28	Precentral gyrus	0.009373	Left	6
2	12,528	−2	30	24	Cingulate gyrus	0.010181	Left	32
2	12,528	6	30	16	Anterior cingulate	0.00818	Right	24
3	7,744	33	7	−31	Uncus	0.007624	Right	28
4	7,592	−36	24	4	Insula	0.008404	Left	13
5	7,296	3	−63	45	Precuneus	0.00818	Right	7
6	7,072	−8	45	−2	Anterior cingulate	0.009139	Left	32
7	7,056	29	49	25	Superior frontal gyrus	0.008519	Right	9
FC
MCI > HC
1	27,392	6	30	16	Anterior cingulate	0.00900	Right	24
MCI<HC
1	13,112	−6	4	30	Cingulate gyrus	0.00934	Left	24
1	13,112	8	−8	40	Cingulate gyrus	0.008697	Right	24
1	13,112	−5	−15	42	Cingulate gyrus	0.008407	Left	24
2	12,904	2	−50	28	Cingulate gyrus	0.00958	Left	31
2	12,904	−4	−76	44	Precuneus	0.009341	Left	7
2	12,904	−12	−64	36	Precuneus	0.009066	Left	7
3	9,000	−0.5	−28.5	69	Paracentral lobule	0.000863	Left	6
4	8,640	−6	22	48	Superior frontal gyrus	0.009013	Left	8
4	8,640	−20	30	50	Superior frontal gyrus	0.007876	Left	8

BA, Brodmann Area; ALE, Anatomical/Activation Likelihood Estimation; MNI, Montreal Neurologic Institute; MCI, amnestic mild cognitive impairment; HCs, healthy controls; ALFF/fALFF, the amplitude of low-frequency fluctuation/fractional amplitude of low–frequency fluctuation; ReHo, regional homogeneity.