FIGURE 3.

(A) Pressure distribution of the focused source (hot colormap) aligned with the centroid of a representative histology thrombus section (red = red blood cells, pink = fibrin). The color bar denotes the normalized peak negative pressure, and the scale bar denotes a 2 mm distance. (B) Representative outcome for Monte Carlo calculation. Red blood cell pixels within regions of bubble expansion were assigned to be “ablated” (white pixels). (C) For simulations of thrombolytic flow from an infusion catheter, ablated pixels were modeled as liquefaction (i.e., fluid). Viable portions of the thrombus were modeled as a porous media. The catheter served as a boundary condition in calculations of the perfusion-diffusion equation, with fluid flow of thrombolytic (700 nMol) from the catheter at a rate of 0.87 cm/s.