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. 2023 Jun 15;9(7):4415–4430. doi: 10.1021/acsbiomaterials.3c00346

Figure 8.

Figure 8

In vitro diffusion study of donepezil into MINERVA 2.0. (a) Experimental procedure, for details see the Experimental Section. (b) Drug diffusion profile through the hydrogel in the Transwell -like system. Fitting curve of the Korsmeyer–Peppas model. In the table are shown the Korsmeyer–Peppas parameters. (c) Side-view schematic of the millifluidic device hosting the hydrogel. (d) Streamline of donepezil concentration in the stationary condition. Side view. (e) Heat maps of drug concentration into the device after drug dosage. (f) Plot showing the experimentally determined and simulated donepezil transported in the outlet of the apical chamber over 72 h.