Appendix S1c.

Summary of P-values for effect of smoking on patient-reported outcome measure outcomes

PROM	P
NRS (0–10)	0.79
EQ-5D-5L VAS (1–100)	0.57
EQ-5D-5L mobility	0.57
EQ-5D-5L self-care	0.56
EQ-5D-5L usual activities	0.48
EQ-5D-5L pain/discomfort	0.64
EQ-5D-5L anxiety/depression	0.02
EQ-5D-5L index	0.37
ODI (%)	0.56

PROM-Patient-reported outcome measure; NRS-Numerical Rating Scale; ODI-Oswestry Disability Index; VAS-Visual Analog Scale; EQ-EuroQol