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. 2023 Jun 5;88(13):9469–9474. doi: 10.1021/acs.joc.3c00493

Table 1. Tests with Various Bases Required for Heterocyclization of 1 in DMF at Room Temperature.

	Yield of 1a (%)/conversion of 1 (%)
Base^a	0.5 h	1 h	1.5 h	24 h	96 h
NaH	34/54	40/62	51/72	64/90	–
K₂CO₃	35/59	60/83	74/>99	–	–
TEA	–	<1/2	–	21/27	43/50
Quinuclidine	3/5	5/8	8/10	25/30	–
DMAP	–	<1/2	–	11/19	27/36
TMG	90/>99	90/>99	–	–	–
DBU	71/83	80/95	–	–	–
TMGN	67/89	79/98	–	–	–
TBD	73/84	75/88	–	–	–
P₁–H	80/>99	80/>99	–	–	–

^a

Structures of all bases are given in Table S1.