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. 2023 Jun 23;88(13):8042–8054. doi: 10.1021/acs.joc.3c00056

Table 1. Reported Synthesis of 6-(Difluoromethyl)-phenanthridines by Radical Isonitrile Insertion.

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entry CF2H reagent condition refs
1 HCF2SO2Cl fac-Ir(ppy)3 26 W fluorescent light Na2CO3, H2O, dioxane, RT (15)
2 HCF2SO2Ar (I) [Ru(bpy)3]Cl2·6H2O 6 W blue LED Na2CO3, DMSO, RT (16)
3 HF2C-S+Ar2 BF4– (II) fac-Ir(ppy)3 12 W blue LED KOH, PEG 600, DCM, RT (17)
4 HF2C-SiMe3 PivOAg, PivCl, CsF DMF, 80 °C (18)