Fig. 4.

HOPE attenuates liver injury by activating JAK2/STAT3 pathway in a rat model of DCD. A–F Western blotting and statistical analyses of JAK2, p-JAK2, STAT3, p-STAT3, and β-actin proteins (n = 3 for each group). p-JAK2 indicates phospho-JAK2, p-STAT3 indicates phospho-STAT3. G, H The levels of AST and ALT in the perfusate (n = 6 for each group). I, J H&E staining and histological injury score in rat liver tissue (n = 6 for each group). Scale = 200 μm (top panel) and 50 μm (bottom panel). ^*p < 0.05 and ^**p < 0.01