Fig. 5.

Predicted stool metabolite profiles. a Volcano plot of enrichments and depletions in predicted stool metabolites linked to severe compared to moderate COVID-19. Adjusted log₂fold change calculated from β-coefficients extracted from multivariable linear modeling plotted against FDR-corrected p-value. Full results in Table S6. b Highlighted box and scatter plots of predicted metabolite abundance by COVID-19 severity. For visualization purposes, technical/true 0 s were imputed with a given taxa’s minimum non-zero value prior to log-transformation. Boxes represent medians and interquartile ranges, while whiskers represent 95%ile