Table 5.
Demographic and clinical characteristics of IPF patient cohorts defined using selected code-based diagnostic algorithms
| Characteristic | DA1 N = 9,498 % of total (n) unless otherwise stated |
DA3 N = 3,449 % of total (n) unless otherwise stated |
DA6 N = 2,069 % of total (n) unless otherwise stated |
DA7 N = 5,488 % of total (n) unless otherwise stated |
|---|---|---|---|---|
| Demographic | ||||
| Median (IQR) age in years | 77 (13) | 76(14) | 76(14) | 76 (14) |
| ≥ 65 years | 86.2% (n = 8,191) | 82.9% (n = 1,516) | 84.4% (n = 2,522) | 83.7% (n = 4,593) |
| Male | 63.2% (n = 6,011) | 63.8% (n = 661) | 64.4% (1,922) | 62.5% (n = 3,434) |
| Median (IQR) survival in years | 2.0 (3.7) | 2.6 (4.8) | 1.8 (3.5) | 2.2 (3.9) |
| Smoking history (ever/current) | 66.2%(n = 6,288) | 62.4%(n = 1,1420 | 68.5(2,046) | 66.4% (n = 3,642) |
| Comorbidities | ||||
| COPD | 19.0% (n = 1,806) | 14.7% (n = 269) | 17.8% (n = 532) | 16.1% (n = 886) |
| Asthma (in past 2 years) | 10.1% (n = 959) | 7.9% (n = 146) | 8.9% (n = 268) | 9.4% (n = 518) |
| Lung cancer | 2.1% (n = 206) | 1.5% (n = 28) | 2.3% (n = 70) | 1.6% (n = 85) |
| Ischemic stroke | 12.0% (n = 1,142) | 10.1% (n = 185) | 12.4% (n = 370) | 11.8% (n = 645) |
| Heart failure | 17.1% (n = 1,629) | 13.6% (n = 249) | 16.3% (n = 489) | 16.4% (n = 899) |
| Ischemic heart disease | 13.6% (n = 1,300) | 11.8% (n = 217) | 14.4% (n = 430) | 13.3% (n = 735) |
| Myocardial infarction | 13.3% (n = 1,267) | 11.2% (n = 206) | 12.4% (n = 370) | 12.7% (n = 693) |
| Gastroesophageal reflux | 17.6% (n = 1,677) | 15.8% (n = 289) | 20% (n = 597) | 18.2% (n = 1,002) |
DA Diagnostic algorithm, IQR Interquartile range, COPD Chronic pulmonary obstructive disease
a Additional criteria include patients ≥ 18 years at IPF diagnosis and evidence of HRCT of the thorax at any time and exclude any patients with other known causes of ILD recorded in Aurum