Skip to main content
. 2023 Jul 12;2023(7):CD011535. doi: 10.1002/14651858.CD011535.pub6
Study Reason for exclusion
Abe 2017 Post hoc subgroup analyses of an already included trial
Abufarag 2010 Other treatment
ACTRN12606000040561 Wrong intervention
Adsit 2017 Post hoc subgroup analyses of an already included trial
Akhyani 2010 Other treatment
Al‐Oudah 2022 Wrong intervention
Altmeyer 1994 Not plaque‐type psoriasis
Angsten 2007 Not a trial
Anonymous 2005 Not a trial
Anonymous 2008 Not a trial
Anonymous 2019 Not a randomised trial
Araujo 2017 Not moderate‐to‐severe psoriasis
Araujo 2019 Not moderate‐to‐severe psoriasis
Arifov 1998 Not a randomised trial
Armati 1972 Other treatment
Asahina 2016 Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
Augustin 2017 Dose de‐escalation strategy study
Avgerinou 2011 Not a randomised trial
Bachelez 2017 Post hoc subgroup analyses of an already included trial
Bagel 2017a Open‐label extension restricted to good responders
Bagel 2017b Not a randomised trial
Bagel 2017c Not moderate‐to‐severe psoriasis
Bagel 2018b Not a randomised trial
Bagherani 2017 Commentary/editorial
Bagot 1994 Other treatment
Banerjee 2021 Wrong comparator
Bartlett 2008 Not a trial
Barzegari 2004 Other treatment
Batchelor 2009 Not a trial
Bayerl 1992 Other treatment
Beissert 2009 Other treatment
Berbis 1989 Assessment < 8 weeks
Bhat 2017 Post hoc subgroup analyses of an already included trial
Bhuiyan 2010 Other treatment
Bian 2018` Open‐label extension restricted to good responders
Bigby 2004 Not a trial
Bissonnette 2006 Other treatment
Bissonnette 2010 Other treatment
Bissonnette 2015 Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
Bissonnette 2017a Open‐label extension restricted to good responders
Bissonnette 2017b Not moderate‐to‐severe psoriasis
Bissonnette 2018 Not moderate‐to‐severe psoriasis
Bjerke 1989 Other treatment
Blauvelt 2016a Ineligible study design
Blauvelt 2016b Open‐label extension restricted to good responders
Blauvelt 2017a Pooled trials
Blauvelt 2017b Open‐label extension restricted to good responders
Blauvelt 2017c Open‐label extension restricted to good responders
Blauvelt 2017d Open‐label extension restricted to good responders
Blauvelt 2017e Pooled trials
Blauvelt 2017f Ineligible study design
Blauvelt 2017g Open‐label extension restricted to good responders
Blauvelt 2017h Open‐label extension restricted to good responders
Blauvelt 2017i Open‐label extension restricted to good responders
Blauvelt 2017j Pooled trials
Blauvelt 2017k Open‐label extension restricted to good responders
Blauvelt 2018a Not a randomised trial
Blauvelt 2018b Open‐label extension restricted to good responders
Blauvelt 2018c Pooled trials
Blauvelt 2018d Pooled trials
Blauvelt 2018e Pooled trials
Blauvelt 2018f Pooled trials
Blauvelt 2018g Pooled trials
Blauvelt 2018h Pooled trials
Blauvelt 2020 Not moderate‐to‐severe psoriasis (good responders selection)
Branigan 2017 Open‐label extension restricted to good responders
Brasil 2012 Ineligible study design
Brasil 2013 Ineligible patient population
Brasil 2016 Ineligible patient population
Buono 2020 Not a randomised trial
Burden 2017 Commentary/editorial
Burkhardt 2017 Ineligible study design
Callis Duffin 2017 Comparison of the same drug with the same dosages
Cassano 2006 Identical dosing regimens
Cassano 2010 Not a trial
Cather 2006 Dose‐ranging after remission
Cather 2018 Ineligible patient population
Chakravadhanula 2017 Ineligible intervention
Chapman 2018 Ineligible study design
ChiCTR‐INR‐16009710 Assessment at 4 weeks
ChiCTR2000030273 2020 Phase 1 trial
Chládek 2002 Basic science (aim of study: to understand the physiopathology of the disease)
Chodorowska 1999a Not a trial
Chodorowska 1999b Not a trial
Choi 2017 Not moderate‐to‐severe psoriasis
Crowley 2018a Not moderate‐to‐severe psoriasis
Crowley 2018b Open‐label extension restricted to good responders
CTRI/2018/01/011373 2 different schemas of administration (same drug, same dosage)
CTRI/2020/07/026598 2020 2 different schemas of administration (same drug, same dosage)
CTRI/2020/12/029472 2020 Wrong intervention
CTRI/2020/12/029611 Same intervention
De Jong 2003 Other treatment
De Mendizabal 2017 Post hoc subgroup analyses of an already included trial
Dubiel 1972 Not a trial
Duffin 2016 Comparison of 2 different ways of drug injection for the same drug and the same dosage
Duffin 2017 Ineligible study design
Ecker‐Schlipf 2009 Other treatment
Edson‐Heredia 2013 Post hoc subgroup analyses of an already included trial
Egeberg 2016 Commentary/editorial
Elewski 2007 Pooled trials
Elewski 2017 Post hoc subgroup analyses of an already included trial
Elewski 2018a Ineligible study design
Elewski 2018b Ineligible study design
Ellis 1986 Assessment < 8 weeks
Ellis 2001 Another intervention
Ellis 2002 Medico‐economic study
Ellis 2012 Other treatment
Engst 1989 Assessment < 8 weeks
Erkko 1997 Basic science (aim of study: to understand the physiopathology of the disease)
EUCTR2007‐004328‐18‐FR Ineligible intervention
EUCTR2012‐005685‐35‐DE Withdrawn trial, NCT01815723
EUCTR2016‐001593‐15‐ES Withdrawn trial, DEEP Study
EUCTR2016‐003592‐21‐GB Withdrawn trial
EUCTR2018‐001021‐10‐SE Not moderate‐to‐severe psoriasis
EUCTR2019‐000817‐35‐DE Not moderate‐to‐severe psoriasis
EUCTR2021‐000542‐18‐LV Not moderate‐to‐severe psoriasis
EUCTR2022‐000695‐19‐LT Not moderate‐to‐severe psoriasis
EXCEED 2021 RCT dedicated to psoriatic arthritis. The randomisation was not stratified on plaque psoriasis with BSA > 10% or PASI ≥ 10 but on psoriatic plaque of ≥ 2 cm diameter.
Ezquerra 2007 Other treatment
Feldman 2017 Not moderate‐to‐severe psoriasis
Fernandes 2013 Not a trial
Fernandez 2017 Not a randomised trial
Finzi 1993 Other treatment
Fitz 2018 Post hoc subgroup analyses of an already included trial
Fleischer 2005 Other treatment
Foley 2017 Pooled trials
Foley 2018 Pooled trials
Fredriksson 1971 Other treatment
Fredriksson 1978 Other treatment
Friedrich 2001 Other treatment
GAIN 2021 Not moderate‐to‐severe psoriasis
Gambichler 2011 Other treatment
Ganguly 2004 Pooled trials
Gil 2003 Not a randomised trial
Gisondi 2020 Not a randomised trial
Glatt 2017 Ineligible study design
Goerz 1978 Not a trial
Gold 2018 Ineligible study design
Goll 2017 Not moderate‐to‐severe psoriasis
Goll 2018 Ineligible study design
Gollnick 1988 Other treatment
Gollnick 1993 Other treatment
Gollnick 2002 Other treatment
Gordon 2014 Ineligible study design
Gordon 2015 Ineligible study design
Gordon 2018a Open‐label extension restricted to good responders
Gordon 2018b Post hoc subgroup analyses of an already included trial
Gordon 2018c Pooled trials
Gordon 2018d Post hoc subgroup analyses of an already included trial
Gottlieb 2002 Other treatment
Gottlieb 2003b Other treatment
Gottlieb 2003c Open‐label extension restricted to good responders
Gottlieb 2004b Pooled trials
Gottlieb 2005 Other treatment
Gottlieb 2006a Ineligible intervention
Gottlieb 2006b Ineligible intervention
Gottlieb 2010 Cross‐over trial
Gottlieb 2016 Pooled trials
Gottlieb 2017a Not moderate‐to‐severe psoriasis
Gottlieb 2017b Not moderate‐to‐severe psoriasis
Gottlieb 2017c Post hoc subgroup analyses of an already included trial
Gottlieb 2017d Pooled trials
Gottlieb 2018a Pooled trials
Gottlieb 2018b Pooled trials
Goupille 1995 Not a randomised trial
Goupille 2018 Not moderate‐to‐severe psoriasis
Griffiths 1998 Other treatment
Griffiths 2002a Pooled trials
Griffiths 2002b Pooled trials
Griffiths 2005 Pooled trials
Griffiths 2010 Open‐label extension restricted to good responders
Griffiths 2016 Post hoc subgroup analyses of an already included trial
Griffiths 2017 Open‐label extension restricted to good responders
Griffiths 2018a Ineligible study design
Griffiths 2018b Post hoc subgroup analyses of an already included trial
Griffiths 2018c Pooled trials
Grim 2000 Basic science (aim of study: to understand the physiopathology of the disease)
Grossman 1994 Other treatment
Guenther 2020 Not moderate‐to‐severe psoriasis
Gulliver 1996 Not a trial
Gupta 2005 Other treatment
Gupta 2007 Other treatment
Gupta 2008 Other treatment
Han 2013 Other treatment
Hashizume 2007 Comparison of 2 methods of administration
Hawkes 2018 Ineligible study design
Heule 1988 Assessment < 8 weeks
Ho 2010 Other treatment
Holzer 2020 No efficacy or safety assessment ‐ the study assessed cardiovascular outcomes
Hsu 2018 Post hoc subgroup analyses of an already included trial
Hunter 1972 Other treatment
Iest 1989 Not a randomised trial
Imafuku 2017 Post hoc subgroup analyses of an already included trial
ISRCTN18043449 Not moderate‐to‐severe psoriasis
Iversen 2018 Ineligible comparator
Jackson 2018 Ineligible study design
Jacobe 2008 Another intervention
JapicCTI‐194706 2019 Comparison of different schemas of administration (same drug, same dosage)
Jin 2017 Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
Joergensen 2022 Wrong intervention
JPRN‐jRCT2071210135 Wrong population
JPRN‐jRCTs041180012 2018 Not moderate‐to‐severe psoriasis
Kaur 2018 Not moderate‐to‐severe psoriasis
Kavanaugh 2009 Not a randomised trial
Kemeny 2019 Post hoc subgroup analyses of an already included trial
Kimball 2008 Drug withdrawn for safety reasons
Kimball 2011 Drug withdrawn for safety reasons
Kimball 2018 Ineligible study design
Kohm 2022 Not moderate‐to‐severe psoriasis
Koo 1998 Other treatment
Kopp 2015 Phase 1 trial
Korotaeva 2021 Not moderate‐to‐severe psoriasis
Kragballe 1989 Other treatment
Krishnan 2005 Pooled trials
Krishnan 2018 Pooled trials
Kristensen 2017 Not moderate‐to‐severe psoriasis
Krueger 1980 Other treatment
Krueger 2002a Another intervention
Krueger 2002b Not a trial
Krueger 2003 Not a trial
Krueger 2012 Phase 1 trial
Krueger 2015 Phase 1 trial
Krueger 2016a Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
Krueger 2016b Phase I trial
Krueger 2022 Not moderate‐to‐severe psoriasis
Krupashankar 2014 Another intervention
Kuijpers 1998 Other treatment
Lajevardi 2015 Other treatment
Lambert 2018 Post hoc subgroup analyses of an already included trial
Langewouters 2005 Other treatment
Langley 2006 Other treatment
Langley 2010 Other treatment
Langley 2016 Open‐label extension restricted to good responders
Langley 2018 Ineligible study design
Langner 2004 Not plaque‐type psoriasis
Lauharanta 1989 Other treatment
Lawrence 1983 Other treatment
Leavell 1970 Other treatment
Lebwohl 2003 Another intervention
Lebwohl 2003a Pooled trials
Lebwohl 2009 Pooled trials
Lebwohl 2012 Other treatment
Lebwohl 2013 Other treatment
Ledo 1988 Other treatment
Legat 2005 Other treatment
Leonardi 2010a Pooled trials
Leonardi 2010b Not a randomised trial
Leonardi 2010c Pooled trials
Leonardi 2011a Open‐label extension restricted to good responders
Leonardi 2011b Not plaque‐type psoriasis
Levell 1995 Other treatment
Li 2018 Post hoc subgroup analyses of an already included trial
Li 2022 Phase 1 trial
Liang 1995 Assessment < 8 weeks
Louw 2017 Open‐label extension restricted to good responders
Lui 2011 Other treatment
Lui 2012 Other treatment
Lynde 2012 Other treatment
Macdonald 1972 Not a randomised trial
Mahrle 1995 Other treatment
Malik 2010 Other treatment
Marecki 2004 Other treatment
Marks 1986 Not a randomised trial
Mate 2017 Not moderate‐to‐severe psoriasis
Mate 2018 Open‐label extension restricted to good responders
McInnes 2013 Pooled trials
McInnes 2017 Not moderate‐to‐severe psoriasis
Mease 2011 Drug withdrawn for safety reasons
Mease 2016a Not moderate‐to‐severe psoriasis
Mease 2016b Not moderate‐to‐severe psoriasis
Mease 2017a Not moderate‐to‐severe psoriasis
Mease 2017b Not moderate‐to‐severe psoriasis
Mease 2017c Not moderate‐to‐severe psoriasis
Mease 2018 Not moderate‐to‐severe psoriasis
Mease 2020 Not moderate‐to‐severe psoriasis
Mease 2022 Not a randomised study
Meffert 1989 Other treatment
Menon 2012 Basic science (aim of study: to understand the physiopathology of the disease)
Menter 2007 Pooled trials
Menter 2014 Drug withdrawn for safety reasons
Menter 2022 Not moderate‐to‐severe psoriasis
Merola 2017 Post hoc subgroup analyses of an already included trial
Merola 2018 Not moderate‐to‐severe psoriasis
Merola 2020 Not moderate‐to‐severe psoriasis
Meyer 2011 Other treatment
Mittal 2009 Other treatment
Moller 2009 Other treatment
Monk 1986 Not a randomised trial
Montgomery 1993 Other treatment
Mrowietz 1991 The 2 study arms compared the same molecule with the same dosage
Mrowietz 2012 Pooled trials
Narang 2012 Other treatment
Nash 2015 Not moderate‐to‐severe psoriasis
NCT00106847 Dose de‐escalation strategy study
NCT00111111 Dose de‐escalation strategy study
NCT00258713 Ineligible intervention
NCT00358670 Open‐label extension restricted to good responders
NCT00377325 Withdrawn trial
NCT00438360 Open‐label extension restricted to good responders
NCT00585650 Ineligible patient population
NCT00645892 Open‐label extension restricted to good responders
NCT00646191 Open‐label extension restricted to good responders
NCT00647400 Open‐label extension restricted to good responders
NCT00832364 Withdrawn trial
NCT01163253 Not a randomised trial
NCT01235442 Ineligible intervention
NCT01276847 Phase I trial
NCT01412944 Open‐label extension restricted to good responders
NCT01443338 Ineligible comparator
NCT01544595 Open‐label extension restricted to good responders
NCT01550744 Open‐label extension restricted to good responders
NCT01624233 Not a randomised trial
NCT01722214 Not moderate‐to‐severe psoriasis
NCT01806597 Ineligible patient population
NCT01815723 Withdrawn trial
NCT01828086 Phase I trial
NCT01936688 Withdrawn trial
NCT02362789 Withdrawn trial
NCT02409667 Open‐label extension restricted to good responders
NCT02798211 Not moderate‐to‐severe psoriasis
NCT03010527 Open‐label extension restricted to good responders
NCT03020199 Ineligible comparator
NCT03025542 Not moderate‐to‐severe psoriasis at the time of placebo use
NCT03073213 Phase I trial
NCT03210259 Not moderate‐to‐severe psoriasis
NCT03482011 Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
NCT03598790 Not moderate‐to‐severe psoriasis
NCT04121143 Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
NCT04488185 Withdrawn (low recruitment)
NCT04614298 Trial withdrawn for reconsideration of drug's business
NCT04839016 Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
NCT04882098 Not moderate‐to‐severe psoriasis
NCT05073315 Not moderate‐to‐severe psoriasis
NCT05184348 Ineligible intervention
NCT05478499 Not moderate‐to‐severe psoriasis
NCT05495568 Not moderate‐to‐severe psoriasis
Nemoto 2018 Phase I trial
Nieboer 1990 Other treatment
Nijsten 2008 Not a trial
Noda 2011 Not a randomised trial
Noor 2017 Not a randomised trial
Novotny 1973 Not a trial
Nyfors 1978 Not a trial
Okubo 2019 Open‐label extension restricted to good responders
Oliver 2021 Ineligible study design
OPT Pivotal‐1 2015 Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
OPT Pivotal‐2 2015 Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
Orfanos 1978 Other treatment
Orfanos 1979 Other treatment
Ortonne 2008 Comparison of 2 schemes of administration
Ortonne 2011 Other treatment
Osamu 2014 Phase 1 trial
Page 2020 Phase 1 trial
Pakozdi 2018 Post hoc subgroup analyses of an already included trial
Papp 2001 Other treatment
Papp 2006 Other treatment
Papp 2008 Other treatment
Papp 2009 Pooled data
Papp 2011a Pooled trials
Papp 2011b Drug withdrawn for safety reasons
Papp 2011c Drug withdrawn for safety reasons
Papp 2012b Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
Papp 2012d Phase 1 trial
Papp 2012e Pooled trials
Papp 2017c Open‐label extension restricted to good responders
Papp 2018a Ineligible outcomes
Papp 2018b Ineligible outcomes
Park 2013 Other treatment
Paul 2012 Other treatment
Paul 2014 Other treatment
Paul 2018 Pooled trials
Perks 2017 Ineligible study design
Pettit 1979 Assessment < 8 weeks
Petzelbauer 1990 Not a randomised trial
Piascik 2003 Not a trial
Ports 2013 Other treatment
Puig 2018 Ineligible outcomes
Punwani 2012 Other treatment
Rabasseda 2012 Not a trial
Radmanesh 2011 Comparison of 2 schemes of administration
Raman 1998 Other treatment
Reich 2004 Ineligible intervention
Reich 2011 Pooled trials
Reich 2014 Other treatment
Reich 2016a Ineligible study design
Reich 2016b Ineligible study design
Reich 2017a Ineligible study design
Reich 2017b Open‐label extension restricted to good responders
Reich 2017c Pooled trials
Reich 2018a Ineligible outcomes
Reich 2018b Long‐term follow‐up of patients included in UNCOVER‐3 (at baseline not moderate‐to‐severe psoriasis and no control group)
Reich 2018c Open‐label extension restricted to good responders
Reich 2019 Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
Reitamo 1999 Other treatment
Reitamo 2001 Other treatment
Rim 2003 Other treatment
Rinsho Iyaku 1991 Other treatment
Ritchlin 2006a Not a randomised trial
Ritchlin 2006b Not a randomised trial
Romiti 2017 Post hoc subgroup analyses of an already included trial
RPCEC00000201 Ineligible intervention
Ryan 2018 Not moderate‐to‐severe psoriasis
Saeki 2017 Not a randomised trial
Salim 2006 Other treatment
Scholl 1981 Other treatment
Schopf 1998 Other treatment
Schulze 1991 Other treatment
Shintani 2011 Comparison of 2 schemes of administration
Shiohara 1992 Not a trial
Shupack 1997 Not a trial
Simonova 2005 Other treatment
Sinclair 2017 Pooled trials
Sofen 2011 Basic science (aim of study: to understand the physiopathology of the disease)
Sofen 2014 Phase 1 trial
Soung 2022 Not moderate‐to‐severe psoriasis
Spadaro 2008 Not a trial
Spuls 2012 Not a trial
Stein Gold 2018 Not moderate‐to‐severe psoriasis
Stein Gold 2021 Not moderate‐to‐severe psoriasis
Sticherling 1994 Not a trial
Strober 2004 Not a trial
Strober 2012 Not a randomised trial
Strober 2017a Pooled trials
Strober 2017b Not moderate‐to‐severe psoriasis
Strober 2017c Ineligible outcomes
Strober 2018 Ineligible study design
Sun 2019 Not psoriasis
Sweetser 2006 Cross‐over trial
Syversen 2020 NCT03074656 ‐ pragmatic trial according to anti‐TNF dosages
Talamonti 2021 Not a randomised study
Talwar 1992 Not a randomised trial
TCTR20190705002 Comparison of 2 different schemas of administration (same drug same dosage)
Tejasvi 2012 Other treatment
Thaçi 2002 The 2 study arms compared the same molecule with the same dosage
Thaçi 2010 Other treatment
Thaçi 2018 Ineligible outcomes
Tong 2008 Other treatment
Tsakok 2018 Commentary/editorial
Vaclavkova 2014 Another intervention
Valenzuela 2017 Post hoc subgroup analyses of an already included trial
Van de Kerkhof 2017 Post hoc subgroup analyses of an already included trial
Van Joost 1988 Assessment < 8 weeks
Vena 2005 Comparison of 2 schemas of administration
Vena 2012 Other treatment
Verma 2021 Wrong comparator
Viglioglia 1978 Not a trial
Viswanath 2022 Not moderate‐to‐severe psoriasis
Witkamp 1995 Other treatment
Wolf 2012 Other treatment
Wright 1966 Not a randomised trial
Wu 2015 Other treatment
Yan 2011 Another intervention
Yesudian 2013 Other treatment
Yiu 2020 Commentary
Yoon 2007 Dose‐escalation study
Yosipovitch 2018 Not moderate‐to‐severe psoriasis
Zachariae 2008 Other treatment
Zhang 2007 Other treatment
Zhang 2009a Other treatment
Zhang 2009b Other treatment
Zhang 2017 Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
Zhang 2020 Other treatment, now excluded in this update because interventions no longer meet inclusion criteria
Zhang 2022 Wrong intervention
Zhu 2009 Pooled trials
Zhuang 2016 Phase 1 trial
Zobel 1987 Not a trial

BSA: body surface area
PASI: Psoriasis Area Severity Index
RCT: randomised controlled trial
TNF: tumour necrosis factor