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. 2023 Jul 11;12(1):2233402. doi: 10.1080/2162402X.2023.2233402

Figure 2.

Figure 2.

Chemokine receptor expression on tissue-resident lymphocyte subsets in lung tumors. (a) Representative overlays of expression of CXCR3, CXCR6, CCR2, and CCR5 on trNK cells (blue), ILCs (green), and CD8+ TRM cells (red) from lung tumor center. Gray histograms represent FMO controls. (b) Frequencies of trNK cells, ILCs, and CD8+ TRM cells expressing CXCR3, CXCR6, CCR2, or CCR5 in tumor-free tissue or tumor tissues (n = 8–16). Friedman test, Dunn’s multiple comparisons test (patient-matched, black); Kruskal–Wallis test (unmatched, gray). Mean indicated as ‘+’. *p < 0.05, **p < 0.01, ****p < 0.0001. (c) SPICE analysis of co-expression patterns of CXCR3, CXCR6, CCR2, and CCR5 on trNK cells, ILCs, and CD8+ TRM cells in different tumor-free tissues and in tumor tissues (n = 6–8).