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. 2023 Jul 11;24(1):2226353. doi: 10.1080/15384047.2023.2226353

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 6. — (a) KLF4 in colon cancer has 134 potential target genes by bioinformatics analysis; (b) KLF4 had a markedly positive correlation with RAB26 by Pearson correlation analysis; (c) the two violin plots show that RAB26 is significantly downregulated in the colon cancer tissue samples; (d) Obtained a binding site and motif between KLF4 and RAB26 using the JASPAR database; (e) KLF4 targeted and bound RAB26 by dual-luciferase assay; (f) the expression of RAB26 in three colon cancer cell lines (SW480, HCT116, SW620) were lower than normal colon fibroblast CCD-18Co, detected by qRT-PCR; (G-H) RAB26 levels were remarkably higher in SW620 and HCT116 cells overexpressing KLF4 tested by qRT-PCR and western blot.