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. 2023 Jul 11;14(1):2228657. doi: 10.1080/21505594.2023.2228657

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 7. — Sau-41 represses S. aureus virulence and alleviates osteolysis in vivo. (a) Illustration of the process of in vivo implant infection model construction. (b) μCT result showing the representative axial, coronal and sagittal views of the implanted femur. (c) 3D reconstruction of μCT data of the infected femur. (d-f) Two hundred sections starting from 30 mm proximal to the femur condyles were quantified for cortical (d) and trabecular (e) bone mineral density and bone volume/total volume (B.V./T.V., F) (n = 6 per group). (g-h): Quantification of the bacterial burden in peri-implant soft tissue (g) and femur (h) (n = 10 per group). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Sau-41⁺: RN4220 carrying the pRmc2_sau-41 plasmid, Sau-41kd: RN4220 carrying pSd1_sau-41, wild type: RN4220 carrying the pRMC2 empty vector.