Bordbar 2008.
| Methods | Allocation: randomised, no further details Blindness: no further details. Duration: six weeks Setting: inpatients, Iran Design: parallel, three groups | |
| Participants | Diagnosis: schizophrenia (DSM‐IV) + PANSS negative >14. N = 80 (10 excluded). Sex: 45M, 45 F. Age: average ˜ 48 yrs | |
| Interventions | 1. Selegiline: 5 mg / day. N = 25 2. Selegiline: 10 mg/day. N = 25. 3. Placebo. N = 30. Stable neuroleptic medication: |
|
| Outcomes | Leaving the study early. Mental state: PANSS (negative and positive endpoint scores). Unable to use: safety (not reported). |
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| Notes | ||
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | "Table of random numbers". |
| Allocation concealment (selection bias) | Unclear risk | No further information. |
| Blinding of participants and personnel (performance bias) All outcomes | Low risk | "Identical placebo". |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | No further information. |
| Incomplete outcome data (attrition bias) All outcomes | High risk | Completer analysis, 10 patients excluded. |
| Selective reporting (reporting bias) | Low risk | Main outcomes reported. |
| Other bias | Low risk | None obvious. |