Ritsner 2010.
| Methods | Allocation: randomised. Blindness: double‐blind. Duration: 8 weeks. Setting: outpatients, Israel Design: parallel. | |
| Participants | Diagnosis: schizophrenia (n = 19) or schizoaffective disorder (n = 5) (DSM‐IV). N = 32. Sex: 6F, 18M (8 excluded not reported). Age: average ˜ 36 years. | |
| Interventions | 1. DHEA (400 mg/day), N =13 2. Placebo. N =11 . Stable neuroleptic medication: mixed antipsychotics. | |
| Outcomes | Leaving the study early. Mental state: PANSS. General functioning: GAF endpoint score. Unable to use: adverse effects (not reported). |
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| Notes | ||
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | "random number generation" |
| Allocation concealment (selection bias) | Low risk | "allocation details coded and kept confidential" |
| Blinding of participants and personnel (performance bias) All outcomes | Low risk | "identical capsules" |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | No further information. |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Eight patients who discontinued the protocol followed up, but excluded from efficacy analysis. |
| Selective reporting (reporting bias) | Low risk | Main outcomes reported. |
| Other bias | Low risk | None obvious. |