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. 2023 Jun 28;11:1174075. doi: 10.3389/fbioe.2023.1174075

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Copyright © 2023 El-Husseiny, Mady, El-Dakroury, Doghish and Tanaka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of ultrasound/acoustic-responsive CaO₂@MSN-HE-PEG (CMHP) nanosystems exploited for heart tissue engineering. (A) Synthesis of the US-sensitive CMHP. (B) Evaluation of CMHP for US-triggered hyperthermia and US-sensitive release of oxygen. (C) Proposed mechanism of US-responsive water diffusion and oxygen release to enhance myocardial survival. (D) Improved survival of the cardiac cells under hypoxic circumstances. (E) Enhancement of cardiac tissue engineering. Copyright © 2020, The Royal Society of Chemistry. Replicated with permission from (Fu et al., 2020).