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. 2023 Jun 28;11:1174075. doi: 10.3389/fbioe.2023.1174075

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Copyright © 2023 El-Husseiny, Mady, El-Dakroury, Doghish and Tanaka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of a dual function enzyme-responsive hydrogel for cardiac tissue engineering. (A) Fabrication scheme of GST-TIMP-bFGF/collagen-GSH MMP enzyme-sensitive hydrogels. (B) Conjugation of GSH on collagen using Sulfo-SMCC. (C) Scanning electron microscopy and mechanical characterization of the produced hydrogels. (D) Assessment of the binding capacity of the bFGF to the GST-TIMP-bFGF/collagen-GSH hydrogels and the MMPs enzyme-induced release profiles of these growth factors from the hydrogel. Copyright © 2019, Wiley-VCH GmbH. Replicated with permission from (Fan et al., 2019a).