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. 2023 Jul;44(7):833–840. doi: 10.3174/ajnr.A7910

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© 2023 by American Journal of Neuroradiology

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FIG 2. — Differences in ADC histogram parameters among histone H3 K27–altered tumors. H3-3A-mutant tumor (A) shows lower ADC_total mode (1252.531 × 10^–6 mm²/s), higher ADC_total skewness (0.673), and higher ADC_total kurtosis (2.721) relative to H3C2/3-altered tumor (B) (ADC_total mode: 1703.875 × 10^–6 mm²/s; ADC_total skewness: −0.231; and ADC_total kurtosis: 0.399). H3-3A-mutated tumor (A) shows lower mean (PG) ADC_enhancement (1216.092 × 10 mm²/s), median (PG) ADC_enhancement (1206 × 10^–6 mm²/s), and mode (PG) ADC_enhancement (1103.723 × 10^–6 mm²/s), relative to H3C2/3-mutated tumor (B): mean (PG) ADC_enhancement (1461.677 × 10^–6 mm²/s), median (PG) ADC_enhancement (1500 × 10^–6 mm²/s), and mode (PG) ADC_enhancement (1665.322 × 10^–6 mm²/s). A, A 3-year-old girl with H3-3A-mutant diffuse midline glioma and OS = 217 days. B, An 8-year-old girl with H3C2/3-mutant diffuse midline glioma and OS = 761 days.