Table 3:

Association of measures of continuous imaging features with variant histone H3–altered versus H3 wild-type tumors

Imaging Metric	Any Histone Mutation		Wild-Type		P Valuea
	No.	Median (Range)	No.	Median (Range)
ADC total (×10–6 mm2/s)
Mean	61	1302.42 (538.06–1797.58)	12	1350.77 (922.96–1729.62)	.98
Median	61	1245 (532–1842)	12	1345 (917–1781)	.97
Mode	61	1250.51 (450.92–1961.24)	12	1305.29 (863.39–1805.47)	.9
Skewness	52	0.68 (−0.89–3.11)	11	0.98 (−0.30–2.57)	.3
Kurtosis	52	1.4 (−0.78–15.62)	11	2.82 (−0.78–10.77)	.1
ADC_enhancement (×10–6 mm2/s)
Mean	45	1152.88 (689.44–1898.26)	6	1199.86 (956.62–1723.18)	.7
Median	45	1142.00 (667–1890)	6	1187.00 (807–1762)	.7
Mode	45	1062.49 (577.86–1746.86)	6	1175.10 (719.70–1805.78)	.6
Skewness	43	0.86 (−0.85–4.73)	6	0.67 (−0.14–1.86)	.7
Kurtosis	43	1.69 (−0.94–29.06)	6	1.35 (0.098–12.45)	.9
FLAIR/T2/T1 PG volume (×103 mm3)
FLAIR/T2	60	35.13 (7.97–77.57)	13	32.77 (10.13–79.62)	.8
Enhancing	46	1.96 (0.04–14.10)	8	1.95 (0.01–4.71)	.4

^aWilcoxon rank-sum test.