Table 5.

Comparison of plasma pro-/anti-inflammatory cytokines at baseline and after HFD intervention

	Non-FDR (n=28)			FDR (n=27)			p value between group
	Baseline	After HFD	p valuea	Baseline	After HFD	p valuea	p valuea	Fold changes from baseline levelb
TNF-α/IL-10	2 (0.9)	1.7 (0.6)	0.17	1.7 (0.6)	2 (0.7)	0.03*	0.73	<0,01*
IL-1β/IL-1RA	0.7 (0.2)	0.6 (0.2)	0.27	0.7 (0.3)	0.6 (0.2)	0.35	0.37	0.48
IFN-γ/IL-4	1 (0.3)	0.9 (0.3)	0.11	0.9 (0.2)	0.9 (0.2)	0.35	0.49	0.07

FDR, first degree relatives; HFD, high-fat diet. The estimated difference in changes was calculated as fold changes: (after HFD/baseline level)-1. All variables are presented as median (interquartile). ^aWilcoxon paired test, ^bMann Whitney. *p<0.05, **p<0.005