| 1 Mental state: 1. General ‐ average endpoint score (BPRS total scores, higher score = poor) |
2 |
50 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.02 [‐6.16, 4.12] |
| 1.1 people with psychotic depression |
1 |
30 |
Mean Difference (IV, Fixed, 95% CI) |
‐6.80 [‐15.31, 1.71] |
| 1.2 people with schizophrenia/schizoaffective disorder |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
2.30 [‐4.15, 8.75] |
| 2 Mental state: 2a. Specific ‐ positive symptoms ‐ average endpoint scores ‐ people with psychotic depression (BPRS positive subscale, higher score = poor) |
1 |
30 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.60 [‐5.67, 0.47] |
| 3 Mental state: 2b. Specific ‐ depression ‐ average endpoint scores ‐ people with psychotic depression (HAMD total, higher score = poor) |
1 |
30 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.20 [‐9.12, 2.72] |
| 4 Global state: 1. General ‐ no clinically significant improvement ‐ people with psychotic depression (< 30% improvement BPRS) |
1 |
30 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.58 [0.32, 1.06] |
| 5 Global state: 2a. Specific ‐ positive symptoms ‐ no clinically significant improvement ‐ people with psychotic depression (< 50% improvement BPRS, PSS) |
1 |
30 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.38 [0.18, 0.81] |
| 6 Global state: 2b. Specific ‐ depression ‐ no clinically significant improvement ‐ people with psychotic depression (< 50% improvement HAMD) |
1 |
30 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.85 [0.59, 1.22] |
| 7 Global state: 3. Leaving the study early |
2 |
50 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.0 [0.13, 68.26] |
| 7.1 people with psychotic depression |
1 |
30 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.0 [0.13, 68.26] |
| 7.2 people with schizophrenia/schizoaffective disorder |
1 |
20 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 8 Adverse events: overall number of events |
2 |
50 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.25 [1.27, 8.33] |
| 8.1 people with psychotic depression |
1 |
30 |
Risk Ratio (M‐H, Fixed, 95% CI) |
4.0 [1.41, 11.35] |
| 8.2 people with schizophrenia/schizoaffective disorder |
1 |
20 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.0 [0.07, 13.87] |
