. 2023 Jul 12;13(31):21153–21162. doi: 10.1039/d3ra02916f

In vitro evaluation of activation potential of benzylbenzimidazolone derivatives 2k, 2m, 2r and 2s against GK.

Activation fold of GK of benzylbenzimidazolone derivatives
Evaluated compounds	nmol min⁻¹ mL⁻¹ of NADH a 100 μg mL⁻¹	nmol min⁻¹ mL⁻¹ of NADH a 200 μg mL⁻¹	Activity increase
Evaluated compounds	nmol min⁻¹ mL⁻¹ of NADH a 100 μg mL⁻¹	nmol min⁻¹ mL⁻¹ of NADH a 200 μg mL⁻¹	100 μg mL⁻¹	200 μg mL⁻¹
2k	30	65	1.31	2.83
2m	—	49	—	2.13
2q	—	—	—	—
2r	45	86	1.96	3.74
Positive control	66	75	2.86	3.26
NADH standard	23