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. 2023 Jul 8;16:1769–1776. doi: 10.2147/CCID.S414011

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© 2023 Benedusi et al.

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Preventive role of M89PF on the increased expression levels of cyclooxy-genase 2 (COX-2). COX-2 expression levels in skin explants samples exposed to O₃, UV, O₃+ UV and/or pretreated topically with M89PF for 24h and analyzed at DAY 1 (A) and DAY 4 (B). Magnification 40X. Scale bar 100 µm. Right panels show the quantification of relative immunofluorescence staining for COX-2 after different treatments (upper panel, DAY 1; below panel, DAY 4). Data are expressed as the mean of the three different subjects ± standard deviation. *p≤0.05 Ctrl vs Pollutant; ^#p≤0.05 M89PF + Pollutant vs Corre-sponding Pollutant. One-way ANOVA followed by Bonferroni post hoc test.