Absorption and distribution profile of all α-benzyl amino coumarin compounds^a.

Entry	HIA	Caco-2 permeability	BBB	P-Glycoprotein	Plasma protein bonding (PPB)
1	95.89	40.71	0.53	NS/NI	84.19
2	96.35	32.78	1.36	NS/NI	88.44
3	96.35	33.20	1.45	NS/NI	95.61
4	95.99	42.25	1.07	NS/NI	84.00
5	95.99	41.68	1.27	NS/NI	84.18
6	95.94	43.59	0.18	NS/NI	83.07
7	96.28	46.85	3.17	NS/NI	86.23
8	96.85	21.52	0.01	NS/NI	88.55
9	96.73	36.52	3.21	NS/NI	98.25
10	96.04	44.79	1.02	NS/NI	85.61
11	95.79	36.93	0.89	NS/NI	78.15
12	96.55	29.35	0.82	NS/NI	100
13	96.26	30.41	0.72	NS/NI	89.90
14	96.50	16.70	0.01	NS/NI	82.31
15	95.89	38.05	0.60	NS/NI	80.51
16	95.87	40.30	0.10	NS/NI	78.83
17	96.50	21.34	0.01	NS/NI	83.07
18	95.83	37.64	0.60	NS/NI	51.66
19	96.46	29.18	0.15	NS/NI	91.28
20	96.16	30.91	0.14	NS/NI	78.08
21	95.23	9.96	0.01	NS/NI	66.81
22	95.88	38.05	0.07	NS/NI	60.53
23	96.59	33.57	0.27	NS/NI	86.02
24	96.59	33.64	0.50	NS/NI	88.18

^aNS = non-substrate; NI = non-inhibitor; S = substrate; I = inhibitor.