Metabolism and toxicity profile of all α-benzyl amino coumarin compounds^a.

Entry	CYP2D6	CYP3A4	AMES toxicity	Carcinogenicity	hERG inhibition
1	NS/NI	NS/NI	Toxic	NC	Weak
2	NS/NI	NS/NI	Non toxic	NC	Strong
3	NS/NI	NS/NI	Non toxic	NC	Strong
4	NS/NI	NS/NI	Toxic	NC	Weak
5	NS/NI	NS/NI	Toxic	NC	Weak
6	NS/NI	NS/NI	Non toxic	NC	Weak
7	NS/NI	NS/NI	Non toxic	NC	Weak
8	NS/NI	NS/NI	Toxic	NC	Strong
9	NS/NI	NS/NI	Non toxic	NC	Strong
10	NS/NI	NS/NI	Non toxic	NC	Weak
11	S/I	NS/NI	Toxic	NC	Weak
12	S/I	NS/NI	Non toxic	NC	Weak
13	S/I	NS/NI	Non toxic	NC	Weak
14	S/I	S/I	Toxic	NC	Weak
15	S/I	NS/NI	Toxic	NC	Weak
16	S/I	S/NI	Toxic	NC	Weak
17	S/I	NS/NI	Toxic	NC	Weak
18	S/I	NS/NI	Toxic	NC	Weak
19	S/I	NS/NI	Non toxic	NC	Weak
20	S/I	NS/NI	Non toxic	NC	Weak
21	NS/NI	NS/NI	Toxic	NC	Weak
22	NS/NI	S/I	Toxic	NC	Weak
23	NS/NI	NS/NI	Non toxic	NC	Weak
24	NSN/I	NS/NI	Non toxic	NC	Weak

^ahERG = Human ether-a-go-go related gene, NS = non-substrate; NI = non-inhibitor; S = substrate; I = inhibitor; NC = non-carcinogenic; C = carcinogenic.