TABLE 3.

Association between week‐4 fecal lactoferrin and long‐term histologic outcomes. ^a

Fecal lactoferrin, μg/mL	Univariate analysis		Model 1 b		Model 2 c		Model 3 d
	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	p value
Histologic improvement
Per 100 units	0.85 [0.78, 0.93]	0.001	0.84 [0.76, 0.92]	<0.001	0.85 [0.76, 0.94]	0.002	0.87 [0.78, 0.97]	0.010
≤84.5	Reference	‐	Reference	‐	Reference	‐	Reference	‐
>84.5	0.38 [0.24, 0.59]	<0.001	0.36 [0.23, 0.56]	<0.001	0.39 [0.24, 0.62]	<0.001	0.42 [0.26, 0.69]	0.001
Low (<19.4)	Reference	‐	Reference	‐	Reference	‐	Reference	‐
Intermediate (19.4–309.3)	0.31 [0.16, 0.57]	<0.001	0.32 [0.17, 0.59]	<0.001	0.36 [0.18, 0.68]	0.002	0.36 [0.18, 0.70]	0.003
High (>309.3)	0.19 [0.09, 0.38]	<0.001	0.19 [0.09, 0.37]	<0.001	0.22 [0.10, 0.45]	<0.001	0.25 [0.11, 0.53]	<0.001
p for trend		<0.001		<0.001		<0.001		0.001
Histologic remission
Per 100 units	0.76 [0.63, 0.89]	0.002	0.74 [0.61, 0.86]	<0.001	0.72 [0.59, 0.86]	0.001	0.72 [0.59, 0.86]	0.001
≤84.5	Reference	‐	Reference	‐	Reference	‐	Reference	‐
>84.5	0.33 [0.18, 0.58]	<0.001	0.29 [0.16, 0.52]	<0.001	0.27 [0.14, 0.52]	<0.001	0.27 [0.14, 0.53]	<0.001
Low (<19.4)	Reference	‐	Reference	‐	Reference	‐	Reference	‐
Intermediate (19.4–309.3)	0.37 [0.20, 0.68]	0.001	0.40 [0.21, 0.74]	0.003	0.37 [0.19, 0.72]	0.004	0.37 [0.19, 0.75]	0.007
High (>309.3)	0.23 [0.10, 0.51]	0.001	0.21 [0.09, 0.48]	<0.001	0.19 [0.07, 0.48]	0.001	0.20 [0.08, 0.52]	0.001
p for trend		<0.001		<0.001		<0.001		0.001

Abbreviations: CI, confidence interval; OR, odds ratio.

^a Long‐term histologic outcomes were assessed at weeks 44 of maintenance treatment in the UNIFI study.

^b Model 1 was adjusted for sex and age.

^c Model 2 was adjusted for model 1 plus baseline partial Mayo score, Mayo endoscopic score and fecal calprotectin.

^d Model 3 was adjusted for model 2 plus treatment allocation and baseline use of corticosteroids.