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. 2023 Jun 2;14(27):7537–7544. doi: 10.1039/d3sc02101g

Variation of aryl estera.

graphic file with name d3sc02101g-u1.jpg
Entry Aryl ester Yieldb (%) Product drc er er
anti- : syn- anti d syn d
1 1 58 4 : 5 49 : 51 79 : 21 93 : 7
2 6 48 10 : 11 48 : 52 87 : 13 97 : 3
3 7 0
4 8 48 12 : 13 74 : 26 89 : 11 93 : 7
5 9 51 14 : 15 68 : 32 89 : 11 95 : 5
a

Reactions performed on 0.5 mmol scale with 1.0 equiv. of 2 and 1.5 equiv. of ester.

b

Combined yield of diastereoisomers by 1H NMR analysis of the crude reaction mixture using 1,3,5-trimethoxybenzene internal standard.

c

Determined by 1H NMR analysis of the crude product.

d

Determined by HPLC analysis on a chiral stationary phase.