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. 2023 Jul 7;64(10):8. doi: 10.1167/iovs.64.10.8

Figure 5.

Figure 5.

Müller cells and microglia interaction in DME. CD40L could combine with CD40 on the surface of Müller cells to promote ATP release, leading to the activation of P2X7 purinergic receptors on retinal microglia and their subsequent expression of inflammatory cytokines. Microglia produced IL-17A and IL-17A bound to IL-17AR on Müller cells, which activated the Act1/TRAF6/IKK/NF-κB signaling pathway in Müller cells and amplified the inflammatory response in the fundus. sCD40L, circulating CD40 ligand; IL-17AR, IL-17A receptor; Act1, NF-κB activator 1; IKK, NF-κB kinase.