Table 3.

Univariate and multivariate logistic regression analyses for clinically significant prostate cancer.

	Univariate logistic regression				Multivariate logistic regression
	OR	95% CI		p	OR	95% CI		p
		Lower	Upper			Lower	Upper
Age, yr
≤65				0.002				0.177
66–70	1.189	0.659	2.145	0.565	1.280	0.648	2.528	0.478
71–75	2.514	1.364	4.635	0.003	1.921	0.955	3.865	0.067
>75	2.521	1.377	4.617	0.003	1.970	0.956	4.059	0.066
PSA, ng/mL
≤6				<0.0001
6.1–8	0.632	0.322	1.241	0.182
8.1–10	0.652	0.320	1.329	0.239
>10	2.093	1.180	3.713	0.012
PSA density, ng/mL/mL
≤0.15				<0.0001				0.034
0.151–0.29	2.317	1.304	4.119	0.004	1.765	0.940	3.317	0.077
0.3–0.44	2.311	1.072	4.984	0.033	1.391	0.591	3.276	0.450
>0.45	5.600	2.919	10.74	<0.0001	2.895	1.399	5.988	0.004
TRUS prostate volume, mL
<20				0.166
21–30	0.306	0.092	1.024	0.055
31–40	0.513	0.157	1.672	0.268
>40	0.351	0.111	1.113	0.075
mpMRI prostate volume, mL
<20				0.220
21–30	0.657	0.217	1.991	0.457
31–40	0.454	0.153	1.349	0.155
>40	0.419	0.148	1.182	0.100
DRE
Positive	2.924	1.878	4.552	<0.0001	1.61	0.95	2.71	0.077
PI-RADS score
PI-RADS 2				<0.0001				<0.0001
PI-RADS 3	3.343	0.979	11.408	0.054	3.46	0.97	12.38	0.056
PI-RADS 4	6.234	1.990	19.527	0.002	5.81	1.78	19	0.004
PI-RADS 5	20.226	6.424	63.684	<0.0001	12.68	3.85	41.8	<0.0001

CI = confidence interval; DRE = digital rectal examination; mpMRI = multiparametric magnetic resonance imaging; OR = odds ratio; PI-RADS = Prostate Imaging Reporting and Data System; PSA = prostate-specific antigen; TRUS = transrectal ultrasound.