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. 2023 Jun 29;19(6):e1011469. doi: 10.1371/journal.ppat.1011469

Fig 5. Predicted coverage of bnAb combinations against circulating viruses.

Fig 5

(A) Diagram illustrating neutralization coverage (created with BioRender.com). “1 Active” is the percent of viruses neutralized by at least one bnAb, “2 Active” is the percent of viruses that can be neutralized by at least two bnAbs, “3 Active” is the percent of viruses that can be neutralized by all three bnAbs. Neutralization coverage by single antibodies (black) was calculated at IC80 <1μg/ml.Using the Bliss Hill Independence model, the active coverage of the antibodies in triple combinations (purple shades for HVTN703/HPTN081 and green shades for HVTN704/HPTN085) was calculated based on the single antibody neutralization data with (B) HVTN703/HPTN081 (clade C) viruses and (C) HVTN704/HPTN085 (clade B) viruses. Coverage at 50% and 90% is indicated by the dotted lines.