Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
ecDNA profiles in different cancers.
| Cancer type | Model | Related ecDNA gene(s) | References |
|---|---|---|---|
| Glioblastoma | Human sample | EGFR, MYC, CDK4, MDM2, PDGFRA | (6, 42) |
| Neuroblastoma | Human sample | n-MYC | (23, 43, 64, 65) |
| Ovarian cancer | Human sample | DNMT1 | (66) |
| Leukaemia | Human cell line | c-MYC | (67) |
| Esophageal adenocarcinoma | Human sample | RUNX1 | (68) |
| Gastric cardia adenocarcinoma | Human sample | ERBB2, EGFR | (69) |
| Colon cancer | Human cell line | DHFR | (70, 71) |
| Lung cancer | Human sample |
MET, PDZRN3, LGR6 |
(72, 73) |
