Table 1.

Summary of SP-2577 Activity Against Pediatric Sarcoma Xenografts

Tumor	Group	KM (Med) (days)	EFS T-C (days)	EFS T/C	P-value (G/W)1	PD2	PD1	PD2	SD	PR	CR	MCR	ORR (%)	Median Response
Ewing Sarcoma (EwS)
A673	A	6.3				10			0	0	0	0
	B	8.7	2.4	1.37	0.037	9	8	1	0	0	0	0	0	PD1
ES-1	A	9.7				10			0	0	0	0
	B	13.3	3.6	1.37	<0.001	8	5	3	0	0	0	0	0	PD1
ES-4	A	6.0				10			0	0	0	0
	B	7.9	2.0	1.33	<0.001	10	8	2	0	0	0	0	0	PD1
ES-7	A	9.9				10			0	0	0	0
	B	12.6	2.7	1.28	0.173	10	8	2	0	0	0	0	0	PD1
EW-5	A	9.5				10			0	0	0	0
	B	9.6	0.1	1.02	0.327	10	10	0	0	0	0	0	0	PD1
EW-8	A	11.8				10			0	0	0	0
	B	12.6	0.9	1.07	0.148	10	10	0	0	0	0	0	0	PD1
NCH-EWS-1	A	14.6				10			0	0	0	0
	B	16.1	1.5	1.10	0.935	9	9	0	0	0	0	0	0	PD1
SK-NEP	A	13.5				9			0	0	0	0
	B	18.5	5.0	1.37	0.002	9	7	0	0	0	0	0	0	PD1
Rhabdomyosarcoma (RMS)
Rh10	A	7.8				10			0	0	0	0
	B	21.8	14.0	2.79	<0.001	10	0	10	0	0	0	0	0	PD2
Rh28	A	12.3				10			0	0	0	0
	B	17.6	5.2	1.43	0.007	6	4	0	0	0	0	0	0	PD1
Rh30	A	14.3				10			0	0	0	0
	B	19.7	5.3	1.37	0.111	8	7	1	0	0	0	0	0	PD1
Rh36	A	20.2				10			0	0	0	0
	B	23.8	3.6	1.18	0.040	9	8	0	0	0	0	0	0	PD1
Rh65	A	12.7				10			0	0	0	0	0
	B	14.5	1.9	1.18	0.030	9	9	0	0	0	0	0	0	PD1
Osteosarcoma (OS)
OS-2	A	31.1				10			0	0	0	0
	B	39.2	8.1	1.26	0.003	10	10	0	0	0	0	0	0	PD1
OS-9	A	15.3				10			0	0	0	0
	B	19.0	3.6	1.24	0.003	10	10	0	0	0	0	0	0	PD1
OS-31	A	17.4				10			0	0	0	0
	B	19.5	2.2	1.12	0.008	10	0	0	0	0	0	0	0	PD1
OS-33	A	19.8				10			0	0	0	0
	B	26.4	6.7	1.34	0.004	10	10	0	0	0	0	0	0	PD1
OS-36	A	14.5				10				0	0	0
	B	16.4	1.8	1.13	0.015	10	10	0	0	0	0	0	0	PD1
OS-60	A	30.1				10			0	0	0	0
	B	35.8	5.6	1.19	0.036	10	0	0	0	0	0	0	0	PD1