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. 2023 Jun 28;14:1211730. doi: 10.3389/fimmu.2023.1211730

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Copyright © 2023 Chew, Cui, Sachaphibulkij, Tan, Kar, Koh, Singh, Lim, Lee, Kumar, Gasser and Lim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing or inhibiting AIM2 in macrophages reverses IL1β production induced by tumor CM. (A) IL-1β levels from control, LPS or PMA Primed THP-1 cells transfected with AIM2 siRNAs or scrambled siRNAs (siRNA Control) and treated with A549 CM. (B, C) IL-1β levels and inflammasome activation in LPS and PMA primed THP-1 cells pre-treated with A151 for 1h prior to treatment with A549 CM. Graph shows the quantification of immunoblots using Image J (fold change vs Actin) (D,E) IL-1β levels in LPS-primed WT and AIM2-/- or Caspase1/11-/- BMDM treated with mouse TRAMP-C2 CM or Poly(dA:dT). Data represents mean ± SEM of at least 3 independent experiments. **p<0.01; ***p<0.001, **** p<0.0001. # p<0.05; ##p<0.01; ###p<0.001; ####p<0.0001.