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DNA-RNA hybrids and dsDNA in the tumor microenvironment activate and trigger AIM2 induced inflammation in macrophages to produce a pro-tumor response. Cancer cells secrete cytosolic DNA into the tumor microenvironment which is taken up by the macrophages. DNA-RNA hybrids and dsDNA bind and activate AIM2 inflammasome in macrophages, which produce pro-tumorigenic responses.
