Table 1.
Main clinical characteristics and perioperative data of the patients.
| Variables | Unmatched group | Matched group | ||||||
|---|---|---|---|---|---|---|---|---|
| MFS (n = 226) | Non-MFS (n = 1,200) | |SMD| | P value | MFS (n = 134) | Non-MFS (n = 134) | |SMD| | P value | |
| Age, y | 35.17 ± 10.02 | 54.41 ± 10.60 | 1.865 | <.001 | 39.29 ± 10.13 | 39.75 ± 10.66 | 0.045 | 0.716 |
| Male sex | 167 (73.9) | 1,032 (86.0) | 0.305 | <.001 | 101 (75.4) | 100 (74.6) | 0.017 | 0.888 |
| Body mass index, kg/m2 | 21.48 ± 3.68 | 24.68 ± 3.60 | 0.882 | <.001 | 22.79 ± 3.46 | 22.87 ± 3.14 | 0.025 | 0.838 |
| Family history of aortic disease | 62 (27.4) | 2 (0.2) | 0.859 | <.001 | 40 (29.9) | 0 (0.0) | 0.919 | <.001 |
| Lens subluxation | 27 (11.9) | 0 (0.0) | 0.520 | <.001 | 18 (13.4) | 0 (0.0) | 0.555 | <.001 |
| Skeletal involvement‡ | 92 (40.7) | 3 (0.3) | 1.156 | <.001 | 40 (29.9) | 1 (0.7) | 0.881 | <.001 |
| Bicuspid aortic valve | 4 (1.8) | 228 (19.0) | 0.588 | <.001 | 0 (0.0) | 34 (25.4) | 0.985 | <.001 |
| Hypertension | 31 (13.7) | 680 (56.7) | 1.006 | <.001 | 29 (21.6) | 26 (19.4) | 0.055 | 0.650 |
| Mitral regurgitation | 62 (27.4) | 199 (16.6) | 0.264 | <.001 | 33 (24.6) | 28 (20.9) | 0.089 | 0.466 |
| Aortic regurgitation | 182 (80.5) | 1,121 (93.4) | 0.389 | <.001 | 115 (85.8) | 117 (87.3) | 0.044 | 0.720 |
| Diabetes | 1 (0.4) | 77 (6.4) | 0.333 | <.001 | 1 (0.7) | 3 (2.2) | 0.315 | 0.622 |
| Hyperlipidaemia | 3 (1.3) | 76 (6.3) | 0.263 | 0.001 | 2 (1.5) | 5 (3.7) | 0.252 | 0.447 |
| Hyperuricaemia | 2 (0.9) | 19 (1.6) | 0.063 | 0.559 | 1 (0.7) | 2 (1.5) | 0.563 | >.999 |
| CKD | 0 (0.0) | 10 (0.8) | 0.130 | 0.379 | 0 (0.0) | 0 (0.0) | NA† | >.999 |
| CHD | 0 (0.0) | 222 (18.5) | 0.674 | <.001 | 0 (0.0) | 5 (3.7) | 0.024 | 0.060 |
| Stroke | 2 (0.9) | 47 (3.9) | 0.199 | 0.016 | 2 (1.5) | 1 (0.7) | 0.563 | >.999 |
| Arrhythmia | 3 (1.3) | 91 (7.6) | 0.307 | <.001 | 1 (0.7) | 2 (1.5) | 0.563 | >.999 |
| Z score* | 11.47 ± 4.82 | 7.01 ± 4.26 | 0.980 | <.001 | 11.06 ± 4.49 | 8.19 ± 5.33 | 0.583 | <.001 |
Values are presented as the mean ± standard deviation or n (%). MFS, Marfan syndrome; SMD, standardized mean difference; CKD, chronic kidney disease; CHD, coronary heart disease.
*
Z score, aortic root z score was measured by sinuses of Valsalva and body surface area (BSA). BSA was calculated using the Dubois and Dubois method.
†
NA, SMD not available for this variable.
‡
Skeletal involvement included wrist and thumb sign, pectus carinatum deformity, hindfoot deformity and scoliosis or thoracolumbar kyphosis.