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HCTZ consumption led to metabolic disorder
(A) Schematic of the HCTZ treatment of mice in both the NCD- and HFD-fed groups.
(B–G) Body weight (B), FBG (C), FINS (D), HOMA-IR (E), OGTT (F), and OGTT-AUC (G) of mice treated with HCTZ or vehicle control (n = 5–8 per group). ∗p < 0.05, ∗∗p < 0.01. Data are represented as mean ± SEM.
(H) Representative immunofluorescence images of insulin in islets. Scale bars = 500 μm.
