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. 2023 Jun 15;26(7):107130. doi: 10.1016/j.isci.2023.107130

Figure 2.

Figure 2

HCTZ consumption altered the gut microbiota profiles

(A) Alpha diversity (Chao index, Shannon index, Ace index, and Simpson index) of fecal samples (n = 5–7 per group).

(B) Principal coordinates analysis of fecal samples (n = 5–7 per group).

(C) Abundance of Enterobacteriaceae in the feces of mice treated with HCTZ or vehicle control under normal chow diet (left) and high-fat diet (right) (n = 5–7 per group). ∗∗p < 0.01. Data are represented as mean ± SEM.

(D) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of the most significantly changed pathways according to 16S rRNA sequencing of fecal samples.