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. 2023 Jun 15;26(7):107130. doi: 10.1016/j.isci.2023.107130

Figure 4.

Figure 4

LPS from the microbiota contributes to HCTZ-induced inflammation and insulin resistance

(A and B) Cecal content (A) and serum (B) LPS levels in mice treated with HCTZ or vehicle control (n = 6–8 per group). ∗p < 0.05. Data are represented as mean ± SEM.

(C) Correlation between serum LPS and HOMA-IR in the HFD-fed group (n = 5–8 per group).

(D–F) Serum TNF-α (D), IL-1β (E), and IL-6 (F) in mice treated with HCTZ or vehicle control (n = 5–8 per group). ∗p < 0.05. Data are represented as mean ± SEM.

(G) Serum LPS levels in recipient mice in the FMT experiment (n = 6–8 per group). ∗p < 0.05. Data are represented as mean ± SEM.

(H–J) Serum TNF-α (H), IL-1β (I), and IL-6 (J) in recipient mice in the FMT experiment (n = 6–8 per group). ∗p < 0.05. Data are represented as mean ± SEM.