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. 2023 Apr 7;41(3):467–473. doi: 10.2337/cd23-0023

TABLE 1.

Manufacturer Recommendations for Missed Doses of GLP-1 Receptor Agonists

Agent Recommended Dosing Interval Manufacturer Recommendations for Missed Doses
Short-acting agents
Exenatide Twice daily
  • Skip missed dose and resume at the next scheduled dose.

Lixisenatide Once daily
  • If a dose is missed, administer within 1 hour prior to next meal.

Long-acting agents
Dulaglutide Once weekly
  • Administer as soon as possible if there are ≥3 days (72 hours) until next scheduled dose.

  • If <3 days before next scheduled dose, skip the missed dose and administer on the next scheduled day.

Exenatide XR Once weekly
  • Administer as soon as possible if there are ≥3 days (72 hours) until the next scheduled dose.

  • If <3 days before next scheduled dose, skip the missed dose and administer on the next scheduled day.

Liraglutide Once daily
  • If dose is missed, resume with the next scheduled dose.

Semaglutide (injectable) Once weekly
  • Administer as soon as possible within 5 days after the missed dose.

  • If >5 days have passed, skip the dose and administer on the next scheduled day.

Semaglutide (oral) Once daily
  • If dose is missed, resume with the next scheduled dose.

Tirzepatide Once weekly
  • Administer as soon as possible within 4 days (96 hours) after the missed dose.

  • If >4 days have passed, skip the dose and administer on the next scheduled day.