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. 2023 Apr 7;41(3):467–473. doi: 10.2337/cd23-0023

TABLE 3.

Alternative Intermediate Doses of Injectable Semaglutide

Semaglutide Pen (Product Concentration) Weekly Semaglutide Intermediate Doses
0.25 and 0.5 mg (2 mg/3 mL)* 0.5 mg 0.4 mg 0.33 mg 0.25 mg 0.12 mg 0.06 mg
1 mg (4 mg/3 mL) 1 mg 0.8 mg 0.66 mg 0.5 mg 0.25 mg 0.12 mg
2 mg (8 mg/3 mL) 2 mg 1.6 mg 1.33 mg 1 mg 0.5 mg 0.25 mg
Number of clicks for desired intermediate dose 74 59 49 37 18 9
Number of available weekly doses using an intermediate dose 4 5 6 8 8 8
*

New semaglutide pen concentration as of March 2023; doses not confirmed by the manufacturer but rather mathematically calculated by the authors.

Injected semaglutide is stable for 56 days (8 weeks) once opened and should be discarded thereafter.