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. 2023 May 24;619(7969):378–384. doi: 10.1038/s41586-023-06112-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, A composite cryo-EM map (left) and the structural model (right) of human OCT4 (green) bound to a nucleosome (grey) assembled with a 182-bp DNA fragment from the LIN28B locus. b, Schematic representation of DNA positioning on the LIN28B nucleosome. Binding sites for OCT4 (OBS1, OBS2 and OBS3) and SOX2, and the Mnl I restriction site are shown. The nucleosome is ‘fuzzy’ as the DNA adopts multiple positions due to spontaneous sliding (top). OCT4 binding stabilizes DNA at a defined position on the nucleosome (bottom). c, Close-up view of OCT4 (green) bound to the nucleosomal DNA (grey; the red line shows the path of the DNA helix axis), showing the kink in the linker DNA introduced by OCT4-POU_HD.