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. 2023 Jun 21;619(7969):394–402. doi: 10.1038/s41586-023-06257-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Decision function coefficients for 400 logistic function fits (regression models) using around 3,500 distinct piRNA–target pairs detected in mouse primary spermatocytes. n = 16 permutations of 4 control (C57BL/6) and 4 pi2^−/−pi9^−/−pi17^−/− animals × 5-repeated × 5-fold cross validation. Box plots show IQR and median. b, Number of piRNAs and siRNAs predicted to cleave mutated versions of the L1Md AI transposon sequence. Data are median and IQR from 100 independent simulations. c, AGO and PIWI proteins use different rules to find and slice targets.