Figure 7.

Implication of dynamically regulated genes during human adipogenesis in obesity (A) Volcano plot of dynamically regulated genes DE between lean vs obese bulk RNA-seq samples. Each dot is a gene colored by its original gene module annotation. The number in green indicates percent of total DE genes in Module 4 and 5 that are enriched in lean samples. The number in red indicates percent of total DE genes in Module 1 and 2 that are enriched in obese samples. (B) Distribution of adipogenic gene signature scores between lean and obese patient in Preadipocytes (left panel) and Adipocyte precursors (APCs; right panel). (C) Distribution of all dynamically regulated genes during white adipogenesis that are also reported in GWAS datasets according to their annotation using gene modules from the current study. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)