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. 2023 Jul 12;14:4083. doi: 10.1038/s41467-023-39416-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Selection of 10 patients with both MDR and non-MDR isolates from the total cohort of 35 patients based on resistance phenotyping data. B Points show the mean growth rate in antibiotic-free culture medium (+/−s.e.m.) of 179 MDR and non-MDR isolates from patients with single strain (n = 6) or mixed strain (n = 4) populations. Line colour corresponds to patient number as shown in key. MDR was associated with reduced growth rate (P = 0.021), and the trade-off associated with MDR was strongest in mixed strain populations (P = 0.001). The data from this assay was analysed using ANOVA (see ‘Methods’ for model details, and Supplementary Table 5 for model output) and the raw data are presented in the source data file.