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. 2023 Jul 12;13:11268. doi: 10.1038/s41598-023-38212-8

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dose–response S-curves of various beating kinetic parameters of cardiac organoids based on their fractional changes (i.e., Δ(X)). We present the curves of the fractional changes for the off- and on-chip beating rates (BR) (a), ΔF/F₀ (b), the beating time percentage (BT₇₅) (c), and the beating power (FBT₇₅) (d). We fit an S-curve to data and obtained IC₅₀ for the off- and on-chip conditions as summarized on the plots. Off- and on-chip curves as well as curves of different parameters compared well with each other with no statistically significant differences (F test). n ≥ 5 organoids per condition.