Table 1.
Patient characteristics.
| Number of patients | Part A (N = 14) | Part B (N = 22) |
|---|---|---|
| Age, years, mean (range) | 62 (44-79) | 56 (32-74) |
| Sex, male | 9 (64%) | 15 (68%) |
| Ethnicity | ||
| White | 9 (64%) | 19 (86%) |
| Black/Asian/other | 5 (36%) | 3 (14%) |
| ECOG PS | ||
| 0 | 4 (29%) | 10 (45%) |
| 1 | 10 (71%) | 12 (55%) |
| Current or former smoker | 3 (21%) | 11 (50%) |
| Locally advanced disease at initial presentation | 6 (43%) | 2 (9%) |
| Site of origin | ||
| Pancreas/Biliary | 2 (14%) | 5 (23%) |
| Other gastrointestinal | 2 (14%) | 11 (50%) |
| Genitourinary | 4 (29%) | 1 (5%) |
| Gynaecologic | 1 (7%) | 1 (5%) |
| Head/neck | 3 (21%) | 0 |
| Unknown | 2 (14%) | 4 (18%) |
| Histology | ||
| Large cell | 2 (14%) | 6 (27%) |
| Small cell | 10 (71%) | 8 (36%) |
| Mixed tumours | 1 (7%) | 3 (14%) |
| Not otherwise specified | 1 (7%) | 5 (23%) |
| Median Ki-67 | 75%* (range 31–91%) | 75% (range 30–95%)** |
| Number of prior lines of systemic therapy, median (range) | 2 (1–8) | 1 (1–4) |
| Prior platinum-based therapy (%) | 14 (100%) | 22 (100%) |
*Available from the tumours of N = 10 patients (71%).
**Available from the tumours of N = 18 patients (82%).