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. 2023 May 15;129(2):335–345. doi: 10.1038/s41416-023-02299-7

Table 4.

Associations between neighbourhood social deprivation and prostate cancer risk in 1996 and around recruitment, overall and by cancer aggressiveness.

1996 At recruitment (2006)
Model 1
Age only
Model 2a
Fully adjusted
Model 3b
Fully adjusted + personal factors of social isolation
Model 1
Age only
Model 2a
Fully adjusted
Model 3b
Fully adjusted + personal factors of social isolation
n Co n Ca OR 95% CI OR 95% CI OR 95% CI n Co n Ca OR 95% CI OR 95% CI OR 95% CI
Overall
 Social deprivation index
   Q1 (low deprivation) 256 216 1 Reference 1 Reference 1 Reference 386 303 1 Reference 1 Reference 1 Reference
   Q2 256 249 1.15 0.90–1.49 1.14 0.88–1.47 1.15 0.89–1.49 383 351 1.14 0.92–1.40 1.12 0.90–1.38 1.12 0.90–1.39
   Q3 255 277 1.30 1.01–1.67 1.25 0.97–1.61 1.23 0.95–1.59 384 374 1.25 1.02–1.54 1.21 0.98–1.50 1.18 0.96–1.46
   Q4 255 274 1.29 1.00–1.65 1.26 0.97–1.62 1.26 0.97–1.63 388 362 1.21 0.98–1.48 1.16 0.93–1.43 1.14 0.91–1.41
   Q5 (high deprivation) 256 350 1.63 1.28–2.08 1.58 1.22–2.02 1.60 1.23–2.07 382 480 1.63 1.33–1.99 1.57 1.37–1.93 1.54 1.24–1.91
   p-trend <0.0001 0.0004 0.0004 <0.0001 <0.0001 0.0003
Census indicators
  % of the population aged 15 and over who are separated, divorced or widowed (per 10 % increase) 1279 1370 1.28 1.13–1.45 1.26 1.10–1.43 1.25 1.10–1.43 1988 1925 1.14 1.04–1.25 1.11 1.01–1.22 1.09 0.99–1.20
  % of single-parent families (per 10 % increase) 1277 1367 1.11 1.03–1.20 1.09 0.99–1.18 1.07 0.98–1.17 1982 1915 1.09 1.03–1.15 1.07 1.00–1.14 1.06 0.99–1.14
  % of the population aged 15 and over living alone (per 10 % increase) 1278 1367 1.13 1.05–1.22 1.12 1.04–1.22 1.14 1.05–1.25 1982 1915 1.17 1.10–1.25 1.17 1.10–1.24 1.16 1.09–1.24
Low grade
 Social deprivation index
 Q1 (low deprivation) 256 167 1 Reference 1 Reference 1 Reference 386 247 1 Reference 1 Reference 1 Reference
 Q2 256 200 1.20 0.92–1.57 1.20 0.91–1.58 1.22 0.93–1.60 383 281 1.12 0.89–1.39 1.10 0.88–1.38 1.11 0.89–1.38
 Q3 259 219 1.31 1.00–1.72 1.28 0.97–1.68 1.27 0.97–1.66 384 281 1.16 0.93–1.45 1.14 0.91–1.43 1.12 0.90–1.40
 Q4 258 220 1.33 1.02–1.74 1.32 1.00–1.73 1.34 1.02–1.75 388 284 1.17 0.94–1.46 1.15 0.91–1.44 1.14 0.91–1.42
 Q5 (high deprivation) 258 265 1.60 1.23–2.07 1.58 1.21–2.08 1.65 1.27–2.14 382 350 1.47 1.18–1.82 1.46 1.16–1.82 1.46 1.17–1.81
   p-trend 0.0005 0.0011 0.0006 0.0008 0.0019 0.0015
Census indicators
  % of the population aged 15 and over who are separated, divorced or widowed (per 10 % increase) 1279 1066 1.28 1.12–1.46 1.27 1.11–1.46 1.28 1.11–1.47 1988 1487 1.14 1.03–1.26 1.12 1.01–1.24 1.10 0.99–1.22
  % of single-parent families (per 10 % increase) 1277 1064 1.09 1.01–1.19 1.09 0.99–1.19 1.08 0.99–1.18 1982 1480 1.04 0.97–1.11 1.03 0.96–1.11 1.03 0.96–1.11
  % of the population aged 15 and over living alone (per 10 % increase) 1278 1064 1.12 1.03–1.22 1.13 1.03–1.23 1.16 1.06–1.26 1982 1480 1.16 1.09–1.24 1.16 1.08–1.24 1.16 1.09–1.25
High grade
 Social deprivation index
   Q1 (low deprivation) 256 49 1 Reference 1 Reference 1 Reference 386 55 1 Reference 1 Reference 1 Reference
   Q2 256 49 1.00 0.65–1.54 0.94 0.61–1.46 0.92 0.60–1.42 383 70 1.26 0.86–1.85 1.19 0.81–1.75 1.18 0.81–1.73
   Q3 259 62 1.25 0.83–1.89 1.15 0.76–1.75 1.10 0.73–1.67 384 93 1.66 1.16–2.39 1.53 1.06–2.21 1.46 1.01–2.09
   Q4 258 55 1.11 0.73–1.70 1.03 0.66–1.57 0.96 0.63–1.47 388 77 1.37 0.94–1.98 1.21 0.83–1.78 1.16 0.80–1.69
   Q5 (high deprivation) 258 85 1.73 1.17–2.56 1.49 1.00–2.24 1.40 0.95–2.07 382 129 2.32 1.64–3.28 2.01 1.40–2.87 1.87 1.32–2.64
   p-trend 0.0033 0.0326 0.0837 <0.0001 0.0003 0.0009
Census indicators
  % of the population aged 15 and over who are separated, divorced or widowed (per 10 % increase) 1279 301 1.28 1.04–1.56 1.18 0.95–1.46 1.15 0.93–1.44 1988 435 1.12 0.97–1.30 1.06 0.91–1.24 1.04 0.89–1.22
  % of single-parent families (per 10 % increase) 1277 300 1.16 1.02–1.31 1.07 0.94–1.23 1.05 0.91–1.21 1982 432 1.26 1.15–1.38 1.17 1.05–1.30 1.16 0.99–1.29
  % of the population aged 15 and over living alone (per 10 % increase) 1278 300 1.16 1.03–1.32 1.12 0.99–1.28 1.10 0.96–1.26 1982 432 1.22 1.10–1.34 1.20 1.08–1.32 1.16 1.04–1.29

PROtEuS, Montreal, Canada, 2005–2012.

aModel 2: adjusted for age, ancestry, family income at index date, highest level of education and neighbourhood material deprivation.

bModel 3: Model 2 + adjusted for marital status, number of children, number of siblings, number of persons living with the subject 2 years before the index date.