Table 4.

Surgery-related factors and use noradrenaline or phenylephrine (n = 550)

Variable	Noradrenaline (n = 201)		Phenylephrine (n = 349)		p value
		Missing		Missing
Could vasopressor agents be stopped?	68 (34%)		238 (68%)		< 0.001
Epidural	102 (51%)		91 (26%)		< 0.001
Goal directed therapy	63 (33%)		74 (21%)		0.002
Intraoperative event*	41 (21%)		48 (13%)		0.027
Temperature < 36 degrees	51 (26%)	n = 1	53 (15%)		0.002
Glucose > 10 mmol/L	30 (16%)	n = 11	21 (6%)	n = 1	< 0.001
Antibiotics < 15 or > 60 min prior incision	52 (27%)	n = 10	71 (21%)	n = 7	0.057
Blood loss > 500 mL	18 (10%)	n = 11	15 (5%)	n = 28	0.037
Oxygen < 94%	5 (3%)		8 (2%)		0.544
Mean arterial pressure < 65 mmhg	24 (12%)		24 (7%)		0.029
Urine production < 30 mL/h	19 (9%)		78 (22%)		< 0.001
OR time > 180 min	73 (36%)		92 (26%)		0.010
Hemoglobin					0.284
Men < 6.5, woman < 6 mmol/L	16 (8%)		31 (10%)
< 7 mmol/L	39 (19%)		67 (21%)		0.340
Surgical approach					< 0.001
Open	55 (16%)		32(14%)
Laparoscopy	127 (63%)		303 (87%)
Laparoscopy with conversion	18 (9%)		13 (4%)		0.223
Fluid administration					0.103
< 250 mL/h	26 (13%)		62 (18%)
250–1000 mL/h	158 (79%)		270 (77%)
> 1000 mL/h	17 (8%)		17 (5%)
Fluid administration > 500 mL/h	97 (48%)		232 (67%)		< 0.001
Blood transfusion					0.048
1 packed cells	13 (7%)		8 (2%)
2 packed cells	1 (0.5%)		2 (0.6%)

Bold values indicate significance of p value (p < 0.005)

Data are presented as number (%) or as medians (range) for categorical and continuous variables, respectively. N is number of inclusions if due to missing data this deviates from total

*Intraoperative events include: hypoxic events, hypertension, hypercarbia, bradycardia, hypotension, embolism, reanimation, more extensive resection than planned, serosa lesions, bladder and ureteral injuries, intraoperative bleeding, splenectomy or bleeding. A p < 0.05 was considered statistically significant